• Stable isotope studies applied to

  2021-07-17

  

  Stable isotope studies, applied to skeletal remains of early Pacific populations, have shown a trend toward a horticultural diet with temporal variation in response to local environmental conditions (Field et al., 2009; Kinaston and Buckley, 2013; Valentin et al., 2010, Valentin et al., 2014; Kinast

• More importantly Santagata et al have

  2021-07-17

  

  More importantly, Santagata et al. have suggested a new breast cancer subtyping method according to ER, androgen receptor (AR), and VDR with a higher prognostic value than the ordinarily used method based on ER, progesterone receptor (PR) and Her2 (Santagata et al., 2014). This implies that such com

• ERR is expressed in several

  2021-07-16

  

  ERRγ is expressed in several adult and embryonic tissues but its biological role is still largely unknown [21]. Overexpression of ERRγ in breast cancer correlates with a favorable outcome [22]. In addition, ERRγ has been reported to inhibit the growth of prostate tumor BGP-15 [23]. In this study we

• br STAR Methods br Author Contributions br Acknowledgments T

  2021-07-16

  

  STAR★Methods Author Contributions Acknowledgments The authors thank Monika Kuhn for excellent technical assistance and Dr. Antje Schäfer for valuable scientific input. H.S. was supported by the DFG (FZ 82; Graduate School of Life Sciences and SCHI 425-6/1), and A.V.S. by Northwestern Univer

• In general terms PLA s participate

  2021-07-16

  

  In general terms, PLA2s participate in the Lands cycle of phospholipid fatty PX 866 recycling [1,15,25], whereby the fatty acid composition at the sn-2 position of phospholipids is tightly controlled by a balance between hydrolytic reactions mediated by PLA2s versus activation of the free fatty aci

• br Conclusions Enzyme prodrug therapy mediated

  2021-07-16

  

  Conclusions Enzyme prodrug therapy mediated by implantable biomaterials combines the benefits offered by the site specific drug delivery techniques and the systemic administration of drugs. From the former, SMEPT inherits the localized mode of drug delivery with lower systemic distribution of the

• PPM-18 Materials and methods br Results Assay of

  2021-07-16

  

  Materials and methods Results Assay of botulinum toxin activity is critical for the risk-assessment, diagnosis, and treatment of botulism cases. The frequently encountered active forms of the toxin are; L chain (inside intoxicated neuronal cells), BoNT (in the blood stream of a botulism patient,

• The enantiomeric ratio ER of chiral compounds accumulated in

  2021-07-16

  

  The enantiomeric ratio (ER) of chiral compounds accumulated in organisms has been found to be different among species (Borga and Bidleman, 2005, Harner et al., 1999, Warner et al., 2005, Wiberg et al., 2000), indicating enantioselective accumulation of chiral compounds are species-specific. The ER o

• We further assessed EBI expression in RRMS patients before a

  2021-07-16

  

  We further assessed EBI2 expression in RRMS patients before and during NTZ treatment. A significant increase of EBI2 expression was observed in memory CD4+ T cell subpopulations, but not in CD8+ T cell or in CD19+ B cell subsets of patients undergoing NTZ treatment, with a parallel gain in the migra

• The lack of effective strategies aiming to directly increase

  2021-07-16

  

  The lack of effective strategies, aiming to directly increase the neuronal survival, is reflected by the fact that the only available therapeutic interventions are indirect. They consist of acute therapeutic interventions involving chemical and/or surgical removal of the thrombotic clot (Taqi et al.

• notch inhibitor br Conclusions and future directions In rece

  2021-07-16

  

  Conclusions and future directions In recent years we saw major advances in our knowledge of H2A-DUB biology, with discovery of novel mammalian H2A-DUBs, better understanding of their biochemical properties, and development of several animal models to address their in vivo functions. However at pr

• br Phenotypic responses alkylation induced cell death and

  2021-07-16

  

  Phenotypic responses: alkylation-induced cell death and mutagenesis E. coli alkB mutants were isolated in a screen for strains specifically sensitive to the cytotoxicity of MMS but not UV-irradiation. This was the first indication that the AlkB protein is a primary cellular defence against alkyla

• Family and twin studies have estimated

  2021-07-16

  

  Family and twin studies have estimated the heritability of obesity to be between 40 and 70% [5], [6], [7]. However, all known risk variants can only account for ∼3% of the variance in BMI [8], [9]. Therefore, alternate methods are needed to identify additional risk factors. In recent decades, Drosop

• Chlorhexidine digluconate Functionally all members of the IL

  2021-07-16

  

  Functionally, all members of the IL-12 family have been annotated along major inflammatory signaling axes but their roles have often weighed on opposing sides of the immunological balance. For instance, IL-12 and IL-23 are classified as pro-inflammatory cytokines [10] as opposed to the rather protec

• Cysteine protease activities have been suggested

  2021-07-16

  

  Cysteine protease activities have been suggested to be important for Giardia’s pathogenesis [[11], [12], [13],16,18,19,21,28,29,35]. Recently several giardial CPs were shown to be released during host cell interactions [9,10]. The three major released CPs have recently been shown to be involved in t

14296 records 606/954 page Previous Next First page 上5页 606607608609610 下5页 Last page